The incidence of serious adverse events was numerically higher with febuxostat than with placebo, but the difference between treatments was not statistically significant.
非布索坦组严重不良反应在数量上多于安慰剂组，但是没有统计学上的显著性差异。
Results The key intermediate 4 for the synthesis of febuxostat was synthesized via a four-step procedure in a total yield of 22.6% and its structure was confirmed by 1H-NMR and ESI-MS.
结果经四步反应合成非布司他关键中间体4，总收率为22.6%，其结构经核磁共振氢谱、质谱确证。
Results The key intermediate 4 for the synthesis of febuxostat was synthesized via a four-step procedure in a total yield of 22.6% and its structure was confirmed by 1H-NMR and ESI-MS.
结果经四步反应合成非布司他关键中间体4，总收率为22.6%，其结构经核磁共振氢谱、质谱确证。
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