Objective To investigate the mutations of EDNRB gene and EDN 3 gene in sporadic Hirschsprung s disease (HD) in Chinese population.
目的检测中国散发先天性巨结肠症是否有EDNRB基因和EDN3 基因突变，以探讨EDNRB及EDN 3与HD发生的关系。
Conclusion promoter methylation of CHFR and EDNRB genes is a common event in HCC, while frequency of promoter methylation of 3-ost-2 is rather low.
结论肝细胞癌中CHFR基因、EDNRB基因启动子的高甲基化是普遍现象，而3 -OST - 2基因启动子甲基化率较低。
Objective To analyze the relationship between polymorphisms of EDNRB gene and Hubei provincial patients of Han ethnicity with sporadic Hirschsprung disease (sHD).
目的研究中国湖北汉族人群内皮素受体- B (EDNRB)基因的多态性与散发性先天性巨结肠症发病的关系。
Conclusions: Both EDNRB and EDN3 genes are correlated with the occurrence and type of HD. Both genes can be used to new research tools for clinical diagnosis and treatment of HD.
结论：EDNRB、EDN 3基因与先天性巨结肠的发生及类型相关，对先天性巨结肠的临床诊断与治疗提供新的研究方向。
Conclusions: Both EDNRB and EDN3 genes are correlated with the occurrence and type of HD. Both genes can be used to new research tools for clinical diagnosis and treatment of HD.
结论：EDNRB、EDN 3基因与先天性巨结肠的发生及类型相关，对先天性巨结肠的临床诊断与治疗提供新的研究方向。
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