Objective To investigate the mutations of EDNRB gene and EDN 3 gene in sporadic Hirschsprung s disease (HD) in Chinese population.

目的检测中国散发先天性巨结肠症是否有EDNRB 基因和EDN 3 基因突变，以探讨EDNRB及EDN 3与HD发生的关系。

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Conclusion promoter methylation of CHFR and EDNRB genes is a common event in HCC, while frequency of promoter methylation of 3-ost-2 is rather low.

结论肝细胞癌中CHFR基因、EDNRB基因启动子的高甲基化是普遍现象，而3 - OST - 2基因启动子甲基化率较低。

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Objective To analyze the relationship between polymorphisms of EDNRB gene and Hubei provincial patients of Han ethnicity with sporadic Hirschsprung disease (sHD).

目的研究中国湖北汉族人群内皮素受体- B (EDNRB)基因的多态性与散发性先天性巨结肠症发病的关系。

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