Chromatin modifications in response to extracellular cues, including during early life, regulate metabolic gene expression and may contribute to metabolic disease susceptibility.
包括新生时期在内的胞外信号会影响染色体的修饰，从而调控和代谢相关的基因表达，进而影响到我们代谢综合征的易感性。
Histone is the nucleus of chromatin, the covalent modifications in its tails form the histone codes that regulate a number of biological processes.
组蛋白是染色质的核心，其尾部的共价修饰组成组蛋白密码，调节许多生物学事件。
To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants tails.
对于不同状态的染色质，核小体中会组装入相应的组蛋白变体，并且各种组蛋白变体的尾部也能发生多种修饰。
To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants' tails.
对于不同状态的染色质，核小体中会组装入相应的组蛋白变体，并且各种组蛋白变体的尾部也能发生多种修饰。
In this context, this report describes the application of an internal grey-level segmentation method for the assessment of real time modifications of chromatin organization in living cells.
在此背景下，本报告介绍了应用程序的内部灰度分割方法的评估实时修改染色质组织在活细胞。
These modifications serve to alter chromatin structure and accessibility, and to act as docking sites for transcription factors or other histone modifying enzymes.
这些修饰为改变染色质结构和易接近性服务，并作为转录因子或其他组蛋白修饰酶的停靠位点。
Operationally, modifications function either by disrupting chromatin contacts or by affecting the recruitment of nonhistone proteins to chromatin.
操作上讲，修饰功能或者通过中断染色质接触或通过影响非组蛋白蛋白质招募到染色质上。
Operationally, modifications function either by disrupting chromatin contacts or by affecting the recruitment of nonhistone proteins to chromatin.
操作上讲，修饰功能或者通过中断染色质接触或通过影响非组蛋白蛋白质招募到染色质上。
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