...组蛋白(H2A, H2B, H3, H4)形成的八隅体和DNA缠绕成核小体所构成，近来越来越多的研究发现 染色质修饰 ( chromatin modifications ) 在调控基因转录的分子机制扮演日趋重要的角色。
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Chromatin modifications in response to extracellular cues, including during early life, regulate metabolic gene expression and may contribute to metabolic disease susceptibility.
包括新生时期在内的胞外信号会影响染色体的修饰，从而调控和代谢相关的基因表达，进而影响到我们代谢综合征的易感性。
Histone is the nucleus of chromatin, the covalent modifications in its tails form the histone codes that regulate a number of biological processes.
组蛋白是染色质的核心，其尾部的共价修饰组成组蛋白密码，调节许多生物学事件。
To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants tails.
对于不同状态的染色质，核小体中会组装入相应的组蛋白变体，并且各种组蛋白变体的尾部也能发生多种修饰。
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