目的：探讨小肠在首过效应中的作用。
Objective: To explore the first-pass effect in Small intestine.
结论DBDCT在大鼠肝微粒体中代谢较快，提示该药可能肝首过效应较强。
ConclusionThe metabolism of DBDCT in rat liver microsomes was faster, suggesting that the liver first-pass effect of the drug may be stronger.
本文旨在寻找制备一个吸收良好、稳定性好、可避免尼莫地平强的首过效应的制剂。
The objective of this study was to develop a good absorbed and stable preparation that can avoid the strong first-pass effect of nimodipine (NMD).
但由于该药肝脏首过效应严重，口服无效，目前国内外临床上供应用的盐酸纳洛酮的剂型为注射液和舌下片。
Because of a serious liver first-pass effect, the dosage forms of Naloxone Hydrochloride is mainly used on domestic and aboard clinical practice in the forms of injection and sublingual tablet.
文献表明槲皮素生物活性低是由于其低的生物利用度，溶解性差与首过效应是影响其生物利用度的主要因素。
Documents show that the low biological activity of quercetin is due to its low bioavailability. Poor solubility and first-pass effect are the main factors that affect its bioavailability.
对于那些生成活性代谢物的药物来讲，经过首过代谢的治疗上的重要性取决于药物和代谢物所引起的期望的和非期望的效应。
For drugs with an active metabolite, the therapeutic consequence of first-pass metabolism depends on the contributions of the drug and the metabolite to the desired and undesired effects.
对于那些生成活性代谢物的药物来讲，经过首过代谢的治疗上的重要性取决于药物和代谢物所引起的期望的和非期望的效应。
For drugs with an active metabolite, the therapeutic consequence of first-pass metabolism depends on the contributions of the drug and the metabolite to the desired and undesired effects.
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