该综述将对FAK与肿瘤的关系以及FAK作为肿瘤治疗靶点的研究进展进行探讨。
This review is to summarize the relationship between FAK and tumor progression, and to discuss the strategies targeting FAK for cancer treatment.
一种治疗药物以突变的基因为靶点，该基因突变后能让肿瘤细胞持续增多。另一种药物能激活病患免疫系统对抗疾病。
One drug specifically targets a mutated gene that tells a cancer cell to grow, the other boosts a patient's immune system in the fight against the disease.
另外，在非肿瘤治疗领域，随着从分子生物学角度更好的理解疾病，对于特定靶点药物的研究有所增加。
Also, in nononcologic therapeutic areas understanding the molecular biology of the disease increases; thus, the chances of developing specific targeted drugs increase.
血管内皮细胞生长因子(VEGF)及其受体在肿瘤血管新生中起重要作用，阻断VEGF的生成已成为抗肿瘤治疗的新靶点。
Vascular endothelial growth factor (VEGF) and its receptor play a critical role in tumor-associated angiogenesis and have become the new targets of anti-tumor therapy.
这一突破或将最终为肿瘤早期诊断与治疗提供一种新的靶点。
This breakthrough may ultimately provide a new diagnostic or therapeutic target to detect cancer early or stop tumor growth.
目的端粒酶在多种肿瘤细胞中高表达，可能是肿瘤分子靶向治疗的一个理想靶点。
Aim Telomerase is highly expression in most tumor cells, and it is an ideal target for cancer molecular targeting therapy.
血管内皮细胞生长因子及其受体在肿瘤新生血管形成中起重要作用，成为肿瘤治疗的新靶点。
Vascular endothelial growth factor (VEGF) and its receptor play a critical role in tumor associated angiogenesis and has become the new targets of anti tumor therapy.
这些新发现提示IGF2能够成为卵巢癌的治疗靶点，特别是对那些对紫杉醇耐药的肿瘤。
Such novel findings suggest that IGF2 represents a therapeutic target in ovarian cancer, particularly in the setting of Taxol resistance.
因此提高胃癌的早期诊断率、寻找新的治疗靶点及预后指标，是当前肿瘤研究的重要课题。
It is a key task for cancer research to search novel prognostic marker, improve early diagnostic rate, and new target of molecular targeted therapy of gastric cancer.
因此，通过对PI3K通路的研究有望寻求肿瘤药物治疗的新靶点。
So the study of PI3K-Akt maybe a new target in searching drug treatment of tumor.
近几年来，基质金属蛋白酶因在肿瘤的生长、转移和血管生成等多个环节中发挥着重要作用而成为肿瘤治疗研究中引人注目的新靶点。
Matrix metalloproteinases (MMPs) has been viewed as a promising target in tumor therapy in recent years due to their key role in tumor growth, angiogenesis, invasion and metastasis.
目的探讨MAGE-1基因编码的肿瘤相关抗原作为肝细胞性肝癌（HCC）主动免疫治疗攻击靶点的可能性。
Objective To explore the possibility of tumor associated antigen encoded by MAGE-1gene used as a tarest for immunotherapy in HCC patients.
另外，我们也特别列举了一大类的非癌基因证据，它们有时往往可以作为治疗肿瘤的药物作用靶点。
In particular, we present evidence for a large class of non-oncogenes that are essential for cancer cell survival and present attractive drug targets.
基质金属蛋白酶(MMP)因其在肿瘤的生长、转移和血管生成等多个环节中发挥着重要作用而成为肿瘤治疗研究中引人注目的靶点。
Matrix metalloproteinases (MMPs) has been viewed as a promising target in tumor therapy due to their key role in tumor growth, angiogenesis, invasion and metastasis.
肿瘤血管是实体肿瘤生长和转移的重要基础，是肿瘤治疗的新靶点。
The tumor vasculature is essential for growth and metastasis, and is new target in tumor treatment.
抗肿瘤抗生素与抗体工程技术的结合可以作为新的技术平台，制备一系列的针对不同靶点的、用于治疗癌症的抗体靶向药物。
The integration of antitumor antibiotic and antibody engineering can serve as new technical platform for manufacture of a series of various target-specific antibody-based drugs for cancer therapy.
这些被抑制和被激活的蛋白可能为肿瘤生物标志物和药物作用靶点，为肿瘤的诊断和治疗提供了新的候选蛋白。
These repressed or activated proteins were the potential tumor biomarkers and drug targets, which would offer the candidate proteins for tumor diagnosis and treatments.
目的：研究遗传印记基因PEG10在肝癌组织中表达的特异性，及在不同肿瘤细胞中的表达情况，为其作为一个潜在的肝癌特异标志物和HCC基因治疗的新的分子靶点提供实验依据。
AIM: To study the specificity of the expression of PEG10 in HCC tissues and evaluate the feasibility for PEG10 as a novel molecular target of gene therapy for HCC.
甚至有人提出OPN可以作为肿瘤分子靶向治疗的一个靶点。
Even someone posed that OPN can be regarded as a target for molecular targeted therapy of many kinds of tumors.
方法查阅2例患者的住院病史和门诊病历，分析原发肿瘤分期、影像学表现、多靶点药物治疗时间、毒副反应、病灶对药物的反应、手术时机、术中所见、病理报告和预后。
Methods Medical records of these 2 patients were reviewed to find the duration of target therapy, toxicity, response of tumor, surgical approach, intraoperative findings, and pathology analysis.
HIF-1可望在将来成为治疗肿瘤的有效靶点之一。
HIF - 1 could become an effective target for cancer treatment in the near future.
肿瘤靶向治疗中治疗靶点、靶向载体和效应分子的选择是关键。
In the research of tumor targeting therapy, how to select therapy target, tumor-homing vehicles and antitumor element is the most important.
结论：化学合成的小肽p5有望作为先导分子，在以KDR为靶点的肿瘤靶向治疗中得到应用。
Conclusion: the peptide P5 that home to KDR expressed on tumor vasculature may also be useful in targeting therapies specifically to tumors.
包括单克隆抗体、酪氨酸激酶抑制剂、融合蛋白、瘤苗在内，以her2为靶点的抗肿瘤治疗研究成为热点，并显示出广阔的应用前景。
Anticancer therapies targeting HER2 have shown promise and become a focus, including monoclonal antibody, tyrosine kinases inhibitor, tumor vaccine, fusion protein.
因此，通过调节自噬活性治疗肿瘤可能成为肿瘤治疗领域的一个新靶点。
Therefore, regulating the activities of autophagy may be a new target of cancer therapy.
肿瘤干细胞学说的提出为肿瘤的治疗提供了新的靶点和方向。
The theory of tumor stem cell offers new target and orientation for tumor therapy.
血管生成与肿瘤的生长、侵袭和转移密切相关，目前，以抑制血管生成为靶点治疗肿瘤有望成为抗肿瘤新疗法之一。
Angiogenesis is required for invasive tumor growth and metastasis. Inhibition of angiogenesis is considered to be a promising approach of antitumor therapy.
这些结果表明，AR可为预测ER阳性乳腺癌内分泌疗效的附加指标，以及ER阴性肿瘤靶向治疗的候选靶点。
These results suggest that AR could be an additional marker for endocrine responsiveness in ER-positive cancers and a candidate for therapeutic targeting of ER-negative tumors.
这些直接以NGF为靶点的治疗在引起细胞增殖下降的同时，还可促进细胞凋亡和抑制肿瘤血管生成。
Such treatments directed against NGF induced a decrease in cell proliferation with a concomitant increase in apoptosis of breast cancer cells and an inhibition of tumor angiogenesis.
这些直接以NGF为靶点的治疗在引起细胞增殖下降的同时，还可促进细胞凋亡和抑制肿瘤血管生成。
Such treatments directed against NGF induced a decrease in cell proliferation with a concomitant increase in apoptosis of breast cancer cells and an inhibition of tumor angiogenesis.
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