目的：研究左乙拉西坦的合成方法。
左乙拉西坦组与丙戊酸钠组差异无统计学意义。
There were no significant differences between the levetiracetam and valproate groups.
本研究系统评价左乙拉西坦治疗儿童癫癎的有效性和安全性。
This study performed a systematic review to evaluate the effectiveness and safety of levetiracetam therapy for childhood epilepsy.
本文简要介绍了左乙拉西坦和波生坦的药理作用及其合成意义。
We briefly discussed pharmacology and significance of both levetiracetam and bosentan in the paper.
目的采用高效液相色谱法手性拆分左乙拉西坦片中的右旋异构体。
Objective A practicable method for separation and quantitative analysis of REV in Levetiracetam tablets by HPLC.
结论：目前证据表明，左乙拉西坦治疗儿童癫癎有效，但仍需更多实验数据支持。
CONCLUSIONS: the current evidence shows that levetiracetam therapy is effective for childhood epilepsy.
筛选以2-溴代丁酸为起始原料，经氨解，酯化，酯胺解，拆分，环合五步反应制得左乙拉西坦。
Screening for 2 - bromo- butyric acid as the starting material, after ammonolysis, esterification, ester amine solution, split, five-step cyclization reaction Levetiracetam.
筛选以2-溴代丁酸为起始原料，经氨解，酯化，酯胺解，拆分，环合五步反应制得左乙拉西坦。
Screening for 2 - bromo-butyric acid as the starting material, after ammonolysis, esterification, ester amine solution, split, five-step cyclization reaction Levetiracetam.
左乙拉西坦是一种新型的口服抗癫痫药物，与其他抗癫痫药物的结构不同，具有全新的抗癫痫机制。
Levetiracetam (Lev) is a novel orally active antiepileptic drug, structurally unrelated to other antiepileptics and with an entirely unique preclinical profile.
左乙拉西坦是一种新型作用机制的抗癫癎药物，其抗癎机制可能是通过影响突触囊泡蛋白SV2A来实现。
Levetiracetam is an antiepileptic drug with novel antiepileptic mechanism, in which binding to SV2A, a synaptic vesicle protein, may result in its anticonvulsant activity.
以蛋氨酸为原料经还原脱硫甲基化、酯化、氨解、酰胺化及分子内缩和成环4步反应合成得到了左乙拉西坦，总收率44.6%。
Levetiracetam was prepared from L-methionine via reduction-dethiomethylation, esterification, ammonolysis, amidation and intramolecular cyclocondensation reaction with 44.6% overall yield.
以蛋氨酸为原料经还原脱硫甲基化、酯化、氨解、酰胺化及分子内缩和成环4步反应合成得到了左乙拉西坦，总收率44.6%。
Levetiracetam was prepared from L-methionine via reduction-dethiomethylation, esterification, ammonolysis, amidation and intramolecular cyclocondensation reaction with 44.6% overall yield.
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