目的:CTCF是一种多功能的转录因子,参与启动子调控、绝缘子功能和遗传印记等过程。
Objective: CTCF is a multifunctional transcription factor, which plays many roles in promoter regulation, insulator function and genetic imprinting.
提示- 1892和- 1837两位点虽不在启动子区,但可能对靶基因表达具有一定的远端调控作用。
It suggests that although -1892 and -1837 loci are far from the promoter, they may play a remote regulation on the target gene expression.
本论文工作着重进行人acat - 1基因P 7启动子活性调控和脂肪酸对人acat 1基因表达影响的两部分探索。
This work was mainly focused on the transcriptional regulation of human ACAT-1 gene P7 promoter activity, and the effect of fatty acids on human ACAT1 gene expression.
负责执行这个调控过程的组成成分包括泛素及其启动酶系统和蛋白酶体系统。
Components in charge of this process include ubiquitin, its startup enzymes, and proteasome system.
该启动子的成功克隆和其报告基因载体的构建,为研究SOD2的基因表达调控机制提供了重要基础和工具。
The reporter gene vector driven by SOD2 promoter will provide an experimental tool for the further study on the regulatory mechanism of the SOD2 expression.
通过对P25基因启动子的活性分析,尤其是对PS GF和BMFA调控元件的功能分析,有利于进一步了解P 25基因表达调控的精细机制。
Analysis of P25 promoter activity, especially functional analysis of PSGF and BMFA regulatory elements, could be helpful in further understanding the mechanism of P25 expression and fine regulation.
在TNNI2和TNNI 3近端启动子的调控元件,保守的人,鼠,猪,但调控元件的差异是其中TNNI 1子存在。
The regulatory elements in the proximal promoter of TNNI2 and TNNI3 were conserved among human, mouse, and pig, but regulatory element differences existed in the TNNI1 promoter among them.
结论EBV相关胃癌和EBV阳性鼻咽癌组织中病毒潜伏期基因启动子的甲基化状态不同,甲基化是调控EBV潜伏期基因启动子活动的重要机制之一。
Conclusion The methylation status of EBV latent gene promoters in EBVaGC and NPC is different, methylation is one of important mechanisms in regularing the activity of EBV latent gene promoters.
在NOS1基因启动子区鉴定了两个正调控区域和两个负调控区域,同时TS A可上调不同长度启动子的转录活性。
Two positive regulation regions and two negative regulation regions were found within NOS1 promoter. TSA may up-regulate the transcription activities of NOS1 promoters of different length.
②凝胶ZND是否能够形成隔断地层流体与井筒流体联系的隔断式凝胶段塞,所形成的凝胶段塞是否具有启动压力梯度及其调控措施仍需实验和现场试验证实;
However, it was still lack of systematic study of rheology of gel ZND. And the rationality, correctness and feasibility of the separating-type gel slug principle need to be verified yet.
启动子在基因表达调控中起关键性作用,它在很大程度上决定所控基因表达的时间、空间和强度。
Promoter plays a key role not only in regulating the level of gene expression but also in controlling the expression in a spatial and temporal manner.
启动子在基因表达调控中起关键性作用,它在很大程度上决定所控基因表达的时间、空间和强度。
Promoter plays a key role not only in regulating the level of gene expression but also in controlling the expression in a spatial and temporal manner.
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