目的观察褪黑激素(MT)对小鼠吗啡戒断反应及血浆、脑组织中NO含量的影响。
AIM to observe the effect of melatonin (MT) on morphine withdrawal syndromes and determine the content of NO in plasma and brain tissue in morphine dependent mice.
结论：针刺通过抑制NOS活力与NO生成，在改善吗啡戒断症状过程中起到良性调节作用。
Conclusion: Acupunctureplay good regulation role in the course of improving morphine abstinence syndrome by inhibiting NOS activity and decreasing NO production.
方法：按照逐日递增原则给予小鼠皮下注射吗啡，以纳洛酮催瘾，建立吗啡戒断后焦虑动物模型。
Methods: The anxiety mice model was formed based on the principle of morphine increase progressively day by day, in which after the mice were induced into morphine dependence, naloxone was given.
目的研究急性或慢性吗啡依赖和戒断大鼠脑组织环腺苷酸反应元件结合蛋白-1 （CREB-1）表达的变化。
Objective To investigate the changes in CREB-1 protein expression in three brain regions induced by acute or chronic morphine dependence and withdrawal.
目的谷氨酸NMDA受体拮抗剂地卓西平（MK801）对大鼠急性吗啡依赖戒断性情绪反应的影响。
ObjectiveTo investigate the effect of NMDA receptor antagonist MK801 on the negative affection induced by withdrawal from acute morphine dependence in rats.
结论：脊髓和脊髓上中枢神经元pi - 3 K信号通路均参与吗啡依赖的形成及戒断反应的表达。
Conclusion: Both spinal and supraspinal neuronal Phosphoinositide 3-kinase (PI3K) pathway played important role in morphine dependent and naloxone-precipitated withdrawal response in mice.
目的研究脑内核团毁损对吗啡成瘾大鼠戒断症状及行为学方面的影响，以及毁损前后的脑形态学变化。
Objective To study effects of stereotaxic lesioning on abstinence symptom and ethology, and observe brain morphological changes after the lesioning in morphine-addicted rats.
美索四氨或哌拉唑嗪以剂量依赖方式抑制吗啡依赖大鼠纳洛酮激发的戒断症状。
In addition, the withdrawal symptoms precipitated by naloxone in morphine dependent rats were blocked by methoctramine(ip) or pirenzepine (it) at single dose injection in a dose dependent manner.
美索四氨或哌拉唑嗪以剂量依赖方式抑制吗啡依赖大鼠纳洛酮激发的戒断症状。
In addition, the withdrawal symptoms precipitated by naloxone in morphine dependent rats were blocked by methoctramine(ip) or pirenzepine (it) at single dose injection in a dose dependent manner.
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