目的：评价来曲唑在生育与妇产科临床应用情况。
OBJECTIVE: To evaluate the use of letrozole in reproduction and clinical obstetrics gynecology.
本文综述了来曲唑的合成方法以及临床研究进展。
The advances in the research of the synthesis and clinical studies of Letrozole were reviewed in this paper.
来曲唑可用于连续5年、每天服用三苯氧胺的绝经后妇女。
Letrozole may be used for postmenopausal women who have completed 5 yr of daily tamoxifen.
目的探讨来曲唑用于有排卵不孕症妇女的促排卵效果及其对生殖激素的影响。
Objective to investigate the effect of letrozole as a drug for ovulation induction in ovulatory infertile women and influence on reproductive hormones.
结果在不含经皮促透剂时，来曲唑的累积透过量随体系中PG浓度的增加而增大。
Results the accumulative permeation of letrozole increased with the increase of PG concentration in the systems containing no enhancers.
结论来曲唑用于不孕妇女的促排卵治疗优于氯米芬，将来有可能替代氯米芬作为一线的诱发排卵药物。
Conclusion Letrozole has more advantage than clomiphene citrate in ovulation treatment of infertile women. It is expected to replace clomiphene citrate as a first-line drug to induce ovulation.
结论来曲唑用于不孕妇女的促排卵治疗优于氯米芬，将来有可能替代氯米芬作为一线的诱发排卵药物。
Conclusion Letrozole has more advantage than clomiphene citrate in ovulation treatment of infertile women. It is expected to replace clomiphene citrate as a first-line drug to induce ovulation.
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