As a nimble 5ft 7ins attacker, Wilshere has had to get used to some harsh treatment.
Arsenal and England will hope Wilshere's emergence signals the start of a fruitful period in their history.
Wilshere later issued a statement on Arsenal's website admitting he deserved to be dismissed for the tackle.
Brady describes Wilshere as quiet, humble and "the model student" but his development was not without its glitches.
Arsenal have not listed any Englishmen but Theo Walcott and Jack Wilshere are among the English under-21 contingent.
Wenger was delighted with his side's performance and was left to purr over 18-year-old Jack Wilshere's display in midfield.
But, after Daniel Sturridge nodded back a corner and Jack Wilshere helped it on, Smalling swept in the winner.
Arsenal's Jack Wilshere has been named in both the under-21 and senior squads.
The 21-year-old follows in the footsteps of Arsenal midfielder Jack Wilshere, who spent last season on loan at the Trotters.
BBC: Loss at Bolton is one of worst Everton displays - Moyes
The match was well into injury time when England midfielder Wilshere took out Zigic's standing leg with a wild lunge.
Arsenal will play second tier Brighton in the fourth round after edging out Swansea 1-0 courtesy of Jack Wilshere's spectacular strike.
Jack Wilshere should be fit for the Gunners after a back problem.
"Jack is a very gifted player with so much natural ability, " said Bolton manager Owen Coyle, who took Wilshere on loan last season.
Just some of the qualities possessed by the greatest modern-day midfielders - and attributes that could eventually enable Wilshere to join the same bracket.
Those closest to the player rubbished the incident, pointing out that Wilshere is teetotal and has no track record of stepping out of line.
Salford looked set for the win when they led 26-14 after tries for Stefan Ratchford, David Hodgson, Andy Coley and two for John Wilshere.
McLeish likened Wilshere's tackle the one by Birmingham's Martin Taylor which resulted in a badly broken leg for then Arsenal striker Eduardo in February 2008.
The Black Cats were almost made to pay as Jack Wilshere released Bendtner, only for Mignolet to claw the Dane's goal-bound shot over the bar.
The public gained their first real glimpse of Wilshere in the 2008 Carling Cup games against Sheffield United and Wigan at the Emirates Stadium.
Wilshere was known to cry with frustration if his team-mates were unable to match his standards but that became less of an issue once Arsenal came calling.
Newcastle striker Carroll and Arsenal's Wilshere are omitted from the squad for Tuesday's friendly in Germany, with speculation mounting they they are in line for senior calls.
And Wilshere was in attendance at the Reebok on Sunday to see some of his former team-mates, having formed a good relationship with Coyle and the club.
BBC: Loss at Bolton is one of worst Everton displays - Moyes
"Everyone connected with those very young age groups felt Jack was exceptionally gifted, " said Brady, Arsenal's academy director and a former midfielder to whom many have likened Wilshere.
With a trip to Manchester United looming on Saturday, Wenger made a double change with 19 minutes left, sending on Arshavin and Jack Wilshere for Eduardo and Eboue.
BBC: SPORT | Football | Europe | Arsenal 3-1 Celtic (agg 5-1)
Though Jack Wilshere's head-shaking trudge down the tunnel suggested otherwise, Wenger didn't believe he would have a hard a time picking up the team for the Bayern game.
Wilshere is not the only Arsenal player facing a fitness test on his return from international duty, with midfielders Andrey Arshavin and Tomas Rosicky also to be monitored.
Leon Pryce put the home side ahead again before Wilshere and Hodgson both took advantage of two passing errors by the Great Britain international to crash over the line.
An off the ball incident led to N'Zogbia confronting Wilshere before leaning his head into the Englishman and giving referee Lee Probert no choice but to show the red card.
The only blot on City's day came when captain Vincent Kompany was sent off for a sliding two-footed tackle on Jack Wilshere, though the Belgium defender appeared to win the ball.
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