"You can do whatever you want because we're not sure what makes a difference, " he said.
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It may be just that little bit of extra effort is what makes a difference.
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"Alessandro is an important player with great international experience and that's what makes a difference at this level, " said Berbizier.
What makes a bigger difference, Mr Demombynes argues, is some combination of broad economic growth and specific public-health policies, notably the increase in the use of insecticide-treated bednets (ITNs) which discourage mosquitoes, which cause malaria.
"Some of the best new businesses start in recessions because what they have really makes a difference if the market is interested in it, " Challenger said.
It's never wholly clear what makes the difference between a Frank Sinatra and Joan Sutherland and any number of completely capable and fully engaged but decisively not comparable other performers of the same music.
What we do everyday makes a positive difference to the families that we serve.
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And see what a difference it makes when you finally stop struggling to consume content in that noisy, windy box.
As a military mom, I know what a difference it makes when individuals or groups reach out to show support to service members and their families.
"It really makes a difference what your background is, " says Till Marco von Wachter, a Columbia University economist who has studied the long-term effect of graduating during a recession.
Oh, what a difference punctuation makes.
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Guess we can say it again: what a difference a day makes.
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My what a difference 18 months makes ( see chart.) For anyone who thinks the stock market is efficient the value of Netflix should make one wonder.
Indeed, what a difference 45 years makes.
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What a difference four years makes.
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What a difference an economy makes.
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