In 2008, NICE said patients would not be able to try a second anti-TNF if their first attempt at anti-TNF therapy failed.

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Is simply making an orally available anti-TNF or anti-IL17 interesting enough?

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In March this year, NICE said adalimumab (Humira), etanercept (Enbrel) and infliximab (Remicade) could only be used in the context of research, even for those patients who had failed on one anti-TNF.

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The scientists found that a cell-signaling protein, or cytokine, known as a hippocampal TNF (tumor necrosis factor) played a limited role.

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It contains a man-made version of the body's own molecular receptor for TNF.

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CytImmune Sciences of Rockville, Maryland, has just begun a study of the efficacy of Aurimune, a solid-gold nanoparticle that carries a dose of tumour necrosis factor (TNF), a substance that has a natural tendency to stick to gold.

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Enbrel works by blocking a long-mysterious protein in the immune system known as tumor necrosis factor, or TNF.

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