"This is a very bittersweet goodbye for me because the kids are already missing it, " Kate Gosselin said.

CNN: Jon and Kate close out 'Plus Eight'

"This is the time when we have to say goodbye to our friends, our colleagues, the excellent crew of shuttle Atlantis that did an excellent job performing three EVAs, installing the new Russian module, having good fun, enjoying living on the station and working in space, " the ISS Expedition 23 commander Oleg Kotov told Ken Ham, who leads the Atlantis crew.

BBC: Atlantis set for 'final' return

If this describes you, the greatest danger inherent in saying goodbye is free time.

FORBES: The Right Way To Say Goodbye To Your Business