Right now, Prozac isn't just the company's biggest moneymaker--it's one of its biggest potential liabilities.

FORBES: Prozac To Fight PMS Under New Name

Launching fluoxetine as a brand-new drug allows Lilly to reach women and their physicians in a way that new publicity for the Prozac brand won't.

FORBES: Prozac To Fight PMS Under New Name

Indianapolis-based Lilly's pipeline of new drugs was not robust enough to make up the interim--meaning that the new drugs that will replace Prozac sales won't start to boost growth until 2003.

FORBES: Magazine Article

Xigris, of course, won't be enough to make for the Prozac shortfall on its own.

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"I would think unless its some radical case you wouldn't want to give them a doggy Prozac, who knows what that's going to do to them, " said a man playing with his dog in a park in New York.

BBC: News | Health | 'Prozac' for pooches

Its sales didn't take off until it could ride on Prozac's coattails.

FORBES: Prozac To Fight PMS Under New Name

"There was this whole idea that Prozac made you better - well, I wasn't sure, " says Joanna Moncrieff, now a senior clinical lecturer in neuroscience at University College London and author of forthcoming book The Bitterest Pills.

BBC: How Prozac entered the lexicon

At its peak, Hazlett says, that drug will bring in only hundreds of millions of dollars, which won't fill the giant chasm left in Lilly's balance sheet by the loss of Prozac.

FORBES: Magazine Article