Topsy, a 5-year-old San Francisco-based Big Data company, has indexed over 200 billion tweets plus other web documents linked from Twitter.
Brian Frezza, co-founder and chief executive of Silicon Valley-based biotech start-up Emerald Therapeutics, says that before he started using software from San Francisco-based Asana that allows people associated with tasks to see what others are doing and comment on it, he spent most of his time in 30-minute meetings with his eight employees.
Another outsider to watch is the NASDAQ-listed, San Francisco-based but Melbourne-born LookSmart.
CNN: ASIANOW - TIME Asia | Asia Buzz: Let the Best Portal Win
BitTorrent is an eight-year old San Francisco-based company offering a range of free-to-use products designed to make it easy and quick to send large files over the internet.
"Instead of just having 1, 000 books, they have 10 times or 100 times that, " says David Risher, co-founder of a San Francisco-based nonprofit called Worldreader that is leading the experiment in Uganda and two other African countries.
Virginia-based OPower has won many contracts with utilities, such as San Francisco-based Pacific Gas and Electric, to use personalized data, competition and even social media to prod consumers into cutting their electricity consumption.
Vancouver, Canada-based precious metals mining company Wheaton River Minerals (amex: WHT - news - people ) and San Francisco-based civil engineering and design firm URS (nyse: URS - news - people ) both remained on the top buy list from two weeks ago.
Wells Fargo (nyse: WFC - news - people ), the San Francisco-based financial services giant, which has purchased 550 million kilowatt-hours of green power (equal to 42% of its annual electricity use), comes in second on the EPA's list and gets approval from the strategies I base on the writings of Peter Lynch and James O'Shaughnessy.
Similarly, Genentech (nyse: DNA - news - people ), the South San Francisco-based biotech giant, held its holiday shindig at a baseball stadium, where employees skated on a temporary ice rink.
"It is the worst gas guzzler I have owned since a 1976 Ford Elite, " he lamented of the Honda Motor (nyse: HMC - news - people ) car in an e-mail to the Bluewater Network, a San Francisco-based environmental advocacy group.
The biotechnology-tools maker licensed an app called Roambi from San Diego-based start-up MeLLmo Inc.
Larry Simns--co-founder of Commercial Fishermen of America, a San Francisco-based nonprofit representing U.S. commercial fishermen--knows the pain.
In addition to Galaxy, the Lui family presides over a business empire that also includes the Hong Kong-listed property firm K Wah International Holdings and San Francisco-based Stanford Hotels.
In America, Levi Strauss, a blue-jeans maker, is increasing its use of specialists like San Fransisco-based Prophet and Beam.
"It's guaranteed that almost everything we see on a computer will show up on a smartphone -- and some new things, " said Jake Widman, a San Francisco-based technology writer and analyst.
"Russian rock songwriting at its best has been very specific to Russian, Soviet and post-Soviet culture, " said Peter Varshavsky, who heads the San Francisco-based label Porto Franco Records and has represented Russian rock bands.
Palm (nasdaq: PALM - news - people ), for instance, hired Avantgarde, a San Francisco-based marketing company, to outfit stars like Matthew Broderick, Mario Batali and Peter Gabriel, among others, with its line of Treo smartphones.
The globe-trotting broker left PaineWebber in March 1998 and until recently worked for San Francisco-based Husic Capital Management.
The new campus is adjacent to The Outlets at Traverse Mountain, just off of I-15 at exit 284, and was created for Adobe by the San Francisco-based architecture and planning firm of WRNS Studio.
FORBES: Adobe Debuts Its Newest Campus - Bring Your Gym Shorts!
Tularik announced after Monday's close that the U.S. Food and Drug Administration has green-lighted the design of what could be the final clinical tests for the South San Francisco-based biotech's liver cancer drug, T67.
Louis-based 8th U.S. Circuit Court of Appeals turned down StoneRidge's claim, the San Francisco-based 9th Circuit court seemed to venture down a different legal path.
San Francisco-based Good initially wrote the software and DeWeese joined in about a year ago.
FORBES: Hot, New 'Word Lens' App Is Founder's First Project In Augmented Reality
This San Francisco-based company has 5 primary brands: Gap, Banana Republic, Old Navy, Athleta and Piperlime.
FORBES: Ethical Clothing Companies that Would Make Angelina Jolie Proud
One model is emerging in the U.S. this August from San Francisco-based Ultra Motor.
He was restless in his job as San Francisco-based Northwest regional sales manager for Reebok.
San Francisco-based Catellus Development was spun off by Santa Fe Pacific Corp. in 1990.
Like Mint or MoneyCenter, San Francisco-based SigFig collects your investing account information into one place.
San Diego-based Qualcomm has been refining mirasol since acquiring the technology from a startup in 2004.
FORBES: Qualcomm Gets A Fourth Mirasol Device: Taiwan's Koobe Jin Yong E-Reader
San Diego-based Qualcomm Inc. began with a discussion in Jacobs' living room in 1985.
Elinor Mills is a San Francisco-based Editor at Large for the IDG News Service.
CNN: U.S. government to set new standard for advanced encryption
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