Tomas Rosicky squandered the best chance for the Czechs during a first-half they totally dominated.
Rosicky and Fabregas, in particular, felt the force of two solid blocks as they looked ready to shoot.
But the gods showed the Black Cats another ray of light when Rosicky inexplicably blazed over the bar.
Substitute Tomas Rosicky saw a shot saved from Carson in a frantic finale.
Rosicky was substituted at half-time in Arsenal's win and Wenger confirmed the midfielder could be out for a month.
Arsenal said on Monday they expected to learn more about the extent of Rosicky's injury in the next 48 hours.
The Czech Republic continued with their preferred 4-2-3-1 formation although an injury to Tomas Rosicky forced a change in personnel.
FORBES: Ronaldo Stoops To Conquer And Breaks Czech Stalemate
The Gunners broke quickly and Thierry Henry's wonderful cushioned first-time pass fell invitingly for Rosicky but he fired wastefully wide.
But the Gunners finally got that third goal when Rosicky volleyed smartly into the bottom right corner from Eduardo's centre.
In the closing minutes Gallas shot over from close range, while Rosicky went agonisingly close with a low fizzing shot.
Tomas Rosicky flashed a shot across goal and Nasri sent a drive just wide as Arsenal picked and probed at Villa.
Arshavin played in Russia's 2-0 home defeat by Belgium while Rosicky was involved in the Czech Republic's 0-0 draw in Denmark.
Reina spilled the ball into his own net after Gunners striker Marouane Chamakh had bundled a Tomas Rosicky cross against the post.
BBC: Liverpool boss Roy Hodgson backs Pepe Reina after error
The England international skipped past a challenge after Tomas Rosicky's 13th minute pass, but Walcott lost his composure at the crucial moment.
The Frenchman revealed that midfielder Tomas Rosicky, who limped off injured in the second half, had "a little concussion from an accidental elbow".
Vassiriki Diaby dispossessed Darius Vassell with a crunching tackle and fed Eboue, whose whipped cross from the right was clinically despatched by Rosicky.
Four minutes after the restart Eduardo beat three men before pulling the ball back for Rosicky to thump a shot against the post.
Czech international Rosicky, 29, has endured a torrid time with injuries and only made his comeback in September after 20 months out of action.
The pattern continued after the break and Michal Kadlec soon forced McGregor to turn his 12-yard header from a Rosicky corner over the crossbar.
However, the pressure eventually told when Rosicky's header was flicked on by substitute Roman Bednar and Hubnik diverted it past McGregor from four yards.
But, right at the last, the Gunners grabbed some consolation from the match as Rosicky's shot came off Lucas Neill and Howard was beaten again.
England winger Wright-Phillips got on the scoresheet four minutes later before Rosicky pulled one back (88) and defender Thomas Vermaelen hit a post for Arsenal.
James's save from Rosicky's shot demonstrated the Portsmouth goalkeeper's superb athleticism.
Tomas Rosicky struck after the break for Arsenal but they were pegged back when Jonathan Tehoue scored for League One side Orient in the 89th minute.
But after Rosicky was denied a penalty, Falcao poked in a Ruben Micael free-kick after Fabianski had picked up a backpass from Campbell inside the box.
Arsenal pulled a goal back with 18 minutes left, Gallas turning home from almost on the line after Kolo Toure touched on substitute Tomas Rosicky's corner.
Arsenal, who had Alex Song sent off for two yellow cards, missed a penalty when Tomas Rosicky blazed over after Ahmed Elmohamady had fouled Samir Nasri.
Steven Pienaar raced clear and dinked the ball over Manuel Almunia to make it 2-1 but Rosicky's shot was deflected in to salvage a draw for Arsenal.
Campbell restored parity when he powered in a header from six yards after Tomas Rosicky had nodded back Thomas Vermaelen's flick from an inswinging Cesc Fabregas corner.
Van Persie and Tomas Rosicky have been out for most of the season, and when Eduardo also got injured there was little back-up for Arsenal's forward line.
应用推荐