One big issue will be transporting the runners to the starting line on Staten Island.
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Looking more deeply at the out-migration and its message, one big issue is clearly jobs.
One big issue among electric-vehicle drivers is how and where to re-charge their cars or trucks.
One big issue is waiting for a Government brave enough to address it.
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One big issue, greater public disclosure, or transparency, of short-selling activity, was met with resistance by many Wall Street insiders, for all the obvious competitive reasons.
One big implementation issue is how currently CFTC-registered FDMs (under CRA) go about converting their registrations to the new DF-category of RFED.
The first HS2 trains through the East Midlands may be 20 years away, but this is one big political issue that's not heading for the buffers.
One big key issue which actually makes us in a stronger position in Britain is that of course we have tackled unemployment very vigorously over the last five years, we've more or less eliminated long term youth unemployment.
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But the country's recently elected President Dilma Rousseff has made the issue one of her big social policy reforms.
"I think there is one issue that really plays big in the Republican Party right now, and that's morality in government, " said Yepsen.
The difference this time is that the Syrian regime, which did not comment on the previous reported incidents, have made a big issue of this one, and cast it in quite a different light, says the BBC's Jim Muir in Beirut.
"The issue here is a large and obvious one that predated Newtown and it will continue to be a big issue going forward, " Gura said.
And Congressman, I know that was a big issue in the House and one that people felt very strongly had to be part of the Affordable Care Act, getting rid of the doughnut hole.
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But more than any individual policy issue, this election illustrated one very big idea.
Mr Delay explained that the issue of water scarcity was closely linked to climate change because "one of the big impacts will be the threat to freshwater supplies".
Many conservatives advise sticking with a big one, claiming it leaves Republicans true to their principles and could become a lively campaign issue in 2000.
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