People are no longer constrained by their physical location or their pre-existing social contacts.

FORBES: Reshaping Reality

They are children, hundreds of thousands of them, growing up in families no longer constrained by nature's original dictate.

CNN: Science led to gay families: Law should follow

The big issue for Provenge, once supplies of it are no longer constrained, is how these cost issues play out over time.

FORBES: Dendreon Foe Fails, But...

With Anybots, users are no longer geographically constrained and can jump from place to place with a click of the mouse.

ENGADGET: Self-balancing Anybots QB now shipping, the future of telepresence is now (video)