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Bigner spent years trying to make monoclonal antibodies against the mutant protein.
FORBES: Magazine Article
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He hooked up a fragment of the mutant protein to a larger protein from a giant sea snail (the keyhole limpet) that looks foreign and can rev up the immune system.
FORBES: Magazine Article
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AIDS. The likelihood that a mutant protein can slip through unnoticed is small: the spectrometer can tell apart proteins that differ by less than a tenth of a proton mass in weight.
ECONOMIST: Viruses: Hunt the mutant | The
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Bristol-Myers originally designed dasatinib to block a mutant protein in other tumors, but in 2001 company pharmacologist Francis Lee noticed that it was hundreds of times more potent than Gleevec in blocking the CML cell growth.
FORBES: The Race Is On