But in recent months, particularly after its new CEO spelled out a major re-focusing strategy, Biogen shares have moved up sharply.
At least 73% of the 151 agency executives surveyed are concerned about security in the cloud, and 45% said their mission-critical applications would require major re-engineering to modernize for the cloud.
FORBES: What Would Happen If Every Federal Agency Moved At Least 3 Applications to the Cloud?
Keith Hayward, head of research at the Royal Aeronautical Society, said that if the issue is no longer about replacing a faulty battery, it raised the prospect of Boeing having to do a major re-design.
At Laggan near Newtonmore, efforts were made to prevent a major fire re-igniting a forest plantation badly damaged on Thursday night.
He plans to meet with the Isles of Scilly Steamship Company to discuss the possibility of the major Scillonian re-fit being speeded up so the ferry can sail next Christmas.
He's also been told that they should state clearly that they plan to increase spending to increase public investment even if it risks a repeat of the "tax bombshell" attack which - along with his soapbox - ensured that John Major was re-elected against the odds in 1992.
Finding satellites can be a major pain sometimes, and the signal can drop while you're driving (see video), which could be a major headache if you're on a trip and you really don't know where you're going.
ENGADGET: An Engadget adventure with TeleNav's G1 GPS software: hands-on, impressions, and video
Which makes Jellinek's first major deal to re-create the old Playboy, well, incongruous.
We're making major new investment in the Mohave Desert, a billion-dollar commitment.
"You've got to accept it at times and the players that we do have out, none of them are major worries we're just being cautious, some might be back training early part of next week, " added Grayson.
Because of the Recovery Act that I signed into law last month -- and that your two outstanding senators, Feinstein and Boxer, worked so hard to pass -- we're making major investments to create jobs right here in California: rebuilding infrastructure, weatherizing homes, and putting more police on the streets, supporting community health centers.
When passengers buy tickets from a major airline, they're often flying regional planes.
"We got a lot of calls from clients this morning, but we're not seeing major changes to positions, " he said.
By now, you've probably plotted out your holiday shopping strategy on the major purchases if you're the type that plans ahead.
ENGADGET: Slickdeals' best in tech for December 3rd: DSLR kit, in-ear headphones and storage options
Asthma, congestive heart failure, depression, coronary artery disease and diabetes--they're the five major chronic conditions that drive the vast majority of health care costs.
We have all kinds of things in so many of our states -- manufacturing wind turbine components and solar panel components -- but we're the only major industrial country in the world without a manufacturing policy.
WHITEHOUSE: President Obama Takes Questions from Senate Democrats
But if you talk to ad reps at these major newspapers, they're saying look, we get to set the rates and this could bring in some new advertisers, and by the way, we need the revenue.
If you are at a media - or if you are at a major function and you're a media member and somebody is doing something that seems outrageous, in many respects it's almost your job to report on that.
Yes, if you're wondering, the major checklist features that users have wanted are here.
"We're going through a major restructuring, but we have to stick with a quality approach, " he says.
The manga was made into a major television series which enjoyed numerous re-runs, and even spawned a theatrical version.
"For the major opening weekend, we're close to the limit, " Mr. Dinges said.
And if you're a fan of Major League Baseball, I think it -- it tarnishes an entire era to some degree.
"You just give it to Major League Baseball and they're like, 'Awesome, '" said Suarez, a Denver native who has never been to Spain.
Rather than rallying the troops for a major electoral test, they're having to soothe the upset and talk down those threatening to desert.
The large majority of the business loans from these smaller banks are not to major corporations -- they're to entrepreneurs like Joe and Doug.
WHITEHOUSE: President Obama Announces New Small Business Lending Initiatives | The White House
"We're clearly seeing a major impact on ozone depletion caused by the eruption in 1991 of Mt Pinatubo in the Philippines, " says Dr Solomon.
American runners still aren't winning major races, but they're coming closer than they've been since East African runners came to dominance in the '80s, right?
"None of the labels you're dealing with are major music companies, " objects Stuart Hersch, president of Universal Music Group, who has scrutinized Gould's business plan.
"None of the labels you're dealing with are major music companies, " objects Stuart Hersch, president of Universal Custom Records, who has scrutinized Gould's business plan.
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