The government scored a major breakthrough with the November 2011 killing of FARC leader Alfonso Cano.
Western diplomats have lowered expectations of a major breakthrough in Almaty, with Iranian presidential elections looming.
No single drug developed in the past decade for advanced colorectal cancer represented a major breakthrough.
For people like Ben Clarke, who runs an Exeter gift shop, it is a major breakthrough.
Time magazine recently recognized this novel approach to aquaculture as a major breakthrough.
The Morton memo was heralded by immigration reform advocates as a major breakthrough.
The other drugs stabilize vision, which was a major breakthrough at the time.
Interestingly, the progress does not need to be a major breakthrough or accomplishment.
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There has been no major breakthrough regarding dealing with what is now the EU debt-strapped nation in the spotlight: Greece.
It is still too early to describe this as a major breakthrough or even foresee where it is all heading.
U.S. officials are doubtful of any major breakthrough in Kazakhstan, in part because of Mr. Khamenei's fixation on the June elections.
Negotiators have agreed to meet in Geneva later this year but no major breakthrough is expected before November's US congressional elections.
He experienced his first major breakthrough at last year's world championships, where he won the 5, 000 and placed second in the 10, 000.
The discovery was made in the Yunnan Province, China, and is being considered as major breakthrough in the study of insect evolution.
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But a major breakthrough on aerodynamics has excited the team, and is due to feature on the F10 for the first time in Valencia.
They say it is a major breakthrough in our understanding of numbers and their properties - but it may take a bit of explaining.
Speaking after the suspension last Saturday, Mr Adams said London and Dublin knew of the "major breakthrough" 12 hours before Mr Mandelson suspended the administration.
If this were a gene therapy trial or a stem cell therapy trial, the results would be heralded as a major breakthrough, benefiting all mankind.
Even that would be a major breakthrough on the political front.
This is considered a major breakthrough because it allows mapping information to be transmitted from a server instead of being stored directly on the hardware.
It so happens that Exxon Mobil has been funding research into this problem at Stanford University for almost a decade now without a major breakthrough.
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Wada boss John Fahey believes getting backing from Fifa, which was one of the last Olympic sport federations to accept the Wada code, is a major breakthrough.
The spokesman played down hopes of a major breakthrough at the talks - saying that to get the various sides there was in itself a major achievement.
After five days with little sign of progress in the investigation into the bombings, police in Britain yesterday announced a major breakthrough, and events seemed to happen with dizzying speed.
But it remains to be seen if the elders are strong enough to maintain security in the town and whether the change in tactics represents a major breakthrough, he adds.
It represented a major breakthrough for Pistorius, who had to take legal action after athletics' ruling body the IAAF banned him from able-bodied competition six months before the 2008 Beijing Olympics.
The announcements by China and the United States follow the world's top economic powers acknowledging earlier this month that there was no hope of a major breakthrough over climate change by year's end.
While this does not prove that the same principle works in humans, or that a drug could be developed to harness this without side-effects, the researchers described the work as a "major breakthrough".
"Pain in itself is debilitating, so to identify it as the route cause of agitation and aggressive behaviour is a major breakthrough which will enable us to support people appropriately, " said its chairman, Nadra Ahmed.
Over the weekend, business groups and organized labor signaled a major breakthrough on the road to comprehensive immigration reform when they announced they had finally struck a deal on guest worker visas, a major obstacle.
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