"The adrenalin took care of the jetlag, " said King, who has just graduated from the "second division" Challenge Tour.

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"It's a bit to do with the heat but also jetlag, " Murray said.

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Last winter I visited Quebec City, a fortified Canadian city that can feel like a trip to France without the jetlag.

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Athletes are the ultimate road warriors, crossing continents and oceans, fighting through jetlag to compete and perform at the highest level.

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The stock has fallen nearly 14% since the FDA declared an unfavorable ruling on Nuvigil for the treatment of jetlag, but the company continues to promote the drug aggressively for its approved uses.

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MacDonald will miss the trip to Wasps in the Premiership due to jetlag and a niggling leg injury, but is expected to be in contention for the LV Cup clash with Leicester Tigers on 8 November at Headingley.

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