But the drug's success highlights how difficult it is for pharmaceutical firms to invent new medicines.
Monday's events show how difficult it will be to clean up local police forces.
Garib also acknowledged how difficult a task the Egyptians had in winning yet another African title.
But a recent trip home during a holiday illustrates just how difficult Wu's life is.
"Knowing how difficult the poses are, I do find something incredible to it, " he says.
Its too soon to tell how difficult the production of this vaccine will prove to be.
Some hard facts, however, point to just how difficult the job of recovery will be.
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But do you know just how difficult it is to find those big shoes?
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The biggest surprise was how difficult it was to get out of my PC mindset.
This shows how difficult it will be for federal spending ever to be curbed.
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He asked reporters again to be aware of how difficult this has been for Lin's family.
George Osborne knows how difficult it would be to get the idea through the Commons.
For evidence of how difficult that is going to be, just re-read up to this point.
Both films detail how difficult it is to fire a tenured teacher for poor performance.
How difficult would that be to accomplish on the public transit system in your town?
Seven years after graduation, I understand how difficult a college marriage, the kind Patton suggests, could be.
The very fact that investors are even considering these approaches shows how difficult their life has become.
Anyone who has had to cut 2.4 percent from the family budget knows how difficult that is.
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What the price of a permit is telling us is how difficult it it to reduce emissions?
And when asked how they plan to vote, they start muttering about how difficult it all is.
He knows firsthand how difficult it can be for a facility to collect payments from its residents.
"Suharto doesn't seem to grasp how difficult and dire the situation really is, " says a well-connected academic.
What is not appreciated, however, is how difficult a choice that is for most women to make.
If your products are service intensive, how difficult is it for your customers to navigate to service facilities?
We saw how difficult it was for us to save the financial system back in the United States.
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Cystic fibrosis is a symbol of how difficult it is to move from genetic discoveries to new medicines.
But with Republicans in turmoil, Mr Pawlenty is proving just how difficult the road to 2012 will be.
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Athletes say the public underestimates how difficult it is even for Olympic champions to return to the Games.
This should give you a sense of how difficult 401(k) plans are to scale across the American workforce.
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Rather than plotting a convincing path to that goal, Chicago showed how difficult it will be to reach.
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