Heart disease has long been thought of as a simple plumbing failure, with arteries clogging up with fat.

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The rugged right winger has long been considered the heart of the franchise.

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Because this patch of Soho, and particularly Denmark St, has long been the beating heart - and the heart of the beat - of London's music scene.

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Finally, the bank's environmental role has long been close to its heart.

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Generally, the focus of attention in such tests is LDL, or bad cholesterol, which at high levels has long been associated with increased chances of heart attacks and strokes.

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Then it's pumped back in to carry more heat away from the plant's fuel rods, which continue producing energy long after the chain reaction at the heart of the units has been stopped.

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The industry leader has long (for decades) been Windsor Vineyards in Healdsburg, CA, the heart of Sonoma.

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The Quartier, located around the Place des Arts and at the intersection of Ste-Catherine and St-Laurent Streets, has been the city's cultural heart for more than 100 years, and has a long and colourful history.

BBC: The Quartier des Spectacles, Montreal's Broadway