At this critical stage, small amounts of capital with hands-on support can have a huge impact.

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But executives have been uncomfortable about the secondary market that has sprung up to buy shares from current and former Facebook employees because such sales have led to inconsistent valuations of the company that are based on small numbers of shares changing hands.

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It's natural for them to expect whatever they can see on a big screen they can see on a small screen, to have access to every bit of information they need in the palm of their hands.

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If you are like me, you have your feet (or hands or head) in both circles, aware that the Venn intersection is fairly small.

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It wasn't until Tarceva extended the lives of patients with non-small cell lung cancer that it became clear that OSI and Genentech actually did have a potential blockbuster on their hands.

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