In answer to your question, Ezetimibe (trade name Zetia) is a cholesterol absorption inhibitor.
The clinical benefits of either ezetimibe alone or combining ezetimibe with statin therapy have recently come into question.
Zetia, also known by the chemical name ezetimibe, works by stopping the absorption of cholesterol in the gut.
No clinically relevant pharmacokinetic interactions were reported between KYNAMRO and warfarin, or between KYNAMRO and simvastatin or ezetimibe.
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We have billion dollar drugs like niacin and fenofibrate and ezetimibe that have less evidence than chelation therapy has now.
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Zetia, known generically as ezetimibe, was invented in Schering's labs (see: "Behind Zetia's Curtain") and is co-marketed with Merck.
Hazlett notes another promising drug: an anti-cholesterol treatment called ezetimibe that makes any of the vaunted statin drugs more attractive.
All the patients were on statins, some also on ezetimibe and they were randomized to niacin and laropripant or placebo.
"This important new combination therapy reflects the growing potential of ezetimibe, " said FredHassanFred Hassan, chairman of Schering-Plough, in a prepared statement.
"Physicians should only use ezetimibe or Vytorin as a last resort, " Steven Nissen, head of cardiology at the Cleveland Clinic, said Monday.
The combination of ezetimibe and simbastatin is marketed under the name Vytorin.
"This important new combination therapy reflects the growing potential of ezetimibe, " said Fred Hassan , chairman of Schering-Plough, in a prepared statement.
Vytorin critics said the problem was that a new component in the drug, the chemical ezetimibe, lowered cholesterol but hadn't been proven to prevent heart attacks or deaths.
Zetia (generically known as ezetimibe) lowers low-density lipoprotein (LDL), the bad cholesterol involved in causing heart attacks and strokes, but less so than existing drugs like Lipitor (generically known as atorvastatin), Crestor, from AstraZeneca, or simvastatin.
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