Some, such as Synercid, which Aventis sold to King Pharmaceuticals today, are especially difficult to administer.
Everyone experiences loneliness at times, but it is especially difficult for aging loved ones.
It is especially difficult and expensive to paint a white car after a black one.
As for the unusual surface, Ms. McKenzie said the sand made turns and jumps especially difficult.
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Especially difficult to find are folks who can do diesel-engine combustion analysis and electromechanical-controls engineering.
He added that Iraq-related concerns were rendering it "especially difficult" to forecast US economic performance.
It is especially difficult to think of this as a way to finance international development aid.
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The holidays were especially difficult for our family because we would always spend them together.
And this holiday season is especially difficult for families who lost everything in the storm.
The task was especially difficult for a Yankee who hated the notion of debt.
When coupled with a top rate of 55 percent, it can be especially difficult for farm and ranch businesses.
"That's especially difficult with units that were already there, " recalled Keane, his mentor.
The long-term unemployed face an especially difficult path back to the labor market.
The short-term tactics are losing their effectiveness, and this means the transition to a consumption-based economy will be especially difficult.
In suburban and rural areas it can be especially difficult for the public to know where to turn for warning messages.
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Considered key to proper learning and crucial to looking up kanji in electronic dictionaries, stroke order can be especially difficult to remember.
The principle of least privilege is not an especially difficult concept to grasp but it can be a real nightmare to implement.
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The big drop was defined by auto sales, which fell as the tight credit conditions made it especially difficult to obtain a car loan.
Unfortunately, this is often especially difficult for young entrepreneurs, as they lack adequate experiences upon which they can honestly assess their strengths and weaknesses.
And is it especially difficult for women, with all our intuition and (amazing) online research skills, to not dig for evidence to confirm our worst fears?
Conditions on Everest have been especially difficult this year because of the less-than-usual amount of snow and ice on the ground for climbers to dig into.
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The situation is especially difficult when your critic is anonymous, as then you first need to persuade a website or message board operator to disclose the person's identity.
Many families have been using children to make carpets for generations, and the fact that the weaving often takes place in people's homes makes it especially difficult to monitor the practice.
And finally, those who suffer from seasonal affective disorder (SAD) or other mental health conditions can find the darkness of winter especially difficult, making them less productive and interested in work.
The hospital treats especially difficult TB cases like hers.
Cold cases are hard to investigate under the best of circumstances, and the shooting of Seth Bishop was especially difficult because it had not been treated as a crime to begin with.
She says it was especially difficult for animals whose owners were forced to leave them at home during the evacuations, even though most people left behind large supplies of food and water.
But it is especially difficult for all of you -- the families of nearly 3, 000 innocents who lost their lives -- your mothers and fathers, your husbands and wives, your sons and your daughters.
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