Since then the space program has had nearly countless ups and downs (no pun intended).

FORBES: Man in Space! 50 Years Later

There will be countless ups and downs, and there will be times when you will question whether starting your own business was really worth the sacrifices you are sure to make.

FORBES: So, You Want To Be An Entrepreneur?

The resilient and charismatic leaders of Onyx, Alkermes and Alnylam, who steered their companies through countless ups-and-downs, while creating billions of dollars of shareholder value, were also recognized.

FORBES: Connect