Patients on Vytorin actually had more heart attacks, cardiovascular deaths and heart procedures than those who got Zocor (the top doses of each were used in the trial).
Patients on Vytorin actually had more heart attacks, cardiovascular deaths, and heart procedures than those who were on Zocor, according to the Enhance study.
And general atherosclerosis, or hardening of the arteries, is a major risk factor for cardiovascular disease, heart attack, and heart failure.
When Topol co-authored an influential paper on Vioxx and Celebrex in 2001, he and his colleagues looked at three certain signs of cardiovascular risk: heart attack, stroke and death.
In a study published last year in the American Heart Association journal Circulation: Cardiovascular Quality and Outcomes, African-Americans with heart disease who practiced Transcendental Meditation regularly were 48% less likely to have a heart attack or stroke, or to die, than those who attended a health-education class.
After 18 months of treatment a study showed an increased risk for cardiovascular events such as heart attack and stroke.
The study showed an increase of cardiovascular events (including heart attacks and strokes) in patients on Vioxx compared to placebo, particularly those who had been on Vioxx for more than 18 months.
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Researchers, for example, recently showed for the first time that a Mediterranean diet can have as powerful an effect as drugs in preventing heart attacks, strokes and deaths from cardiovascular disease in subjects at high risk of heart disease.
Steve Humphries, British Heart Foundation professor of cardiovascular genetics at UCL, said: "Men who carried the E4 type are at higher risk of heart disease, but only if they are smokers".
Weight-loss stimulants speed up metabolism but can cause strokes, heart attacks and cardiovascular problems.
These and other data captured the interest of Servier, a global pharmaceutical company committed to heart failure and cardiovascular disease.
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During the follow-up period, 148 of the men committed suicide and 6, 845 died from cardiovascular causes, such as heart attack or stroke.
This can help you more objectively assess your cardiovascular fitness and determine optimal heart rate training zones for improving fitness and endurance.
And those with ED were 1.6 times more likely to suffer from a serious cardiovascular problem such as a heart attack or stroke.
Furthermore, 27 percent of the surgery group but only 13 percent of the monitoring group developed a cardiovascular problem such as a heart attack, heart disease or stroke.
Those who stuck to wine had the biggest reduction in cardiovascular events, such as heart attacks, compared with non-drinkers, heavy drinkers or those who drank other types of alcohol.
The strong advice - from these researchers and from other experts - is that those WITH a history of cardiovascular disease - such as heart attack or stroke - should continue with daily aspirin.
The company is starting up a large trial with an anti-inflammatory drug it licensed from Bayer that targets the bad gene, hoping to show that the drug slashes the risk of heart attacks in cardiovascular patients.
Lost in the hoopla: 22% of heart patients on Lipitor still had heart attacks or other cardiovascular events in a two-year period.
To further cloud the matter, heart attacks and other cardiovascular problems will only be counted in the first 14 days after patients stop their painkiller.
He also criticizes the study for only taking into account heart attacks and other cardiovascular problems that occurred within two weeks after patients stopped taking Vioxx.
By the end of the study, 215 of the study participants had experienced a heart attack or other cardiovascular problem, and 325 had died from any cause.
In Merck's own trial of 8, 000 rheumatoid arthritis patients, patients on Vioxx had more than twice the risk of getting a heart attack or other cardiovascular event than those who took naproxen.
Overall, Merck and Harvard researchers calculated that they could rule out with 95% certainty the possibility that anacetrapib could cause the 25% increase in heart attacks and other cardiovascular events seen with torcetrapib.
In one study of Bextra and its injected cousin parecoxib, heart bypass patients treated for as little as ten days with the drugs had nearly quadruple the risk of having a heart attack or other cardiovascular-adverse events in the next month.
This summer, an article in the Journal of the American Medical Association said that both Vioxx and its main competitor, Pharmacia (nyse: PHA - news - people) drug Celebrex, may cause heart attacks and other cardiovascular problems in rare cases.
In the 4, 162-person PROVEIT study, Harvard cardiologists found that patients hospitalized for heart attacks or unstable angina who took a 80-milligram dose of Lipitor were 16% less likely to suffer heart attacks or other cardiovascular "events" over two years than those who took a lower dose of Bristol-Myers Squibb 's (nyse: BMY - news - people ) Pravachol.
Everyone has heard of statins: they are a class of cholesterol-lowering drugs that offer clear benefits in people who already have suffered heart attacks or other serious cardiovascular problems.
Despite several studies showing an association with alcohol intake and reduced cardiovascular risk, guidance from the American Heart Association warns people not to start drinking if they do not already drink alcohol.
As revealed last month, the AtheroGenics study showed no benefit from the drug in heart patients based on its main goal, which included stent procedures, chest pain, heart attacks, strokes and cardiovascular death.
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