In the United States, HoFH, an orphan indication, occurs in approximately one in one million individuals.
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AZT, began as an orphan drug for what was then an obscure disease of the immune system.
Kynamro is an orphan drug approval, meaning it was developed to treat a disorder affecting fewer than 200, 000 people.
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Anyone remotely involved in politics knows the truth of the saying that failure is an orphan while success has many fathers.
Unless ablation's backers can produce hard data showing how well it works, the procedure may continue to be a bit of an orphan.
REBECCA, the narrator of Helen Dunmore's excellent new novel, is an orphan, abandoned by her mother and left in a shoebox outside an Italian restaurant.
John Caird will direct Daddy Long Legs, which will see Broadway actress Megan McGinnis reprising her praised performance as an orphan romanced by her anonymous benefactor.
It is likely to be easier to garner approval in an orphan use than a broader one such as jet lag, where there is more potential for overuse.
In addition, the BAB program is something of an orphan.
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John Rivers (Jamie Bell) and his family, and by playing, as powerful flashbacks, her harsh childhood as an orphan as well as her time as a governess at Thornfield.
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Then, once more, she turned back to people she knew and asked for more money, this time to start a Sharing Foundation scholarship fund for an orphan girl to attend college.
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Medical devices are something of an orphan sister to the glamour of drugs, but they include some of the genuine miracles of modern medicine: pacemakers, artificial joints, cardiac stents, scanners, and radiotherapy machines.
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An orphan who never knew who his real parents were, he was brought up in Pennsylvania by Mabel Michener, a poor Quaker widow, who was given his date of birth as February 3rd, 1907.
The illegitimate daughter, Cosette would be an orphan.
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Their manufacturers will learn the painful lesson that their tablets are too small and increase the size next year, thereby abandoning both customers and developers who jumped on the seven-inch bandwagon with an orphan product.
If Pfizer were to gain approval of such an orphan drug, for example, the company might be granted more time to market its blockbuster cholesterol-lowering drug Lipitor before any manufacturer was permitted to produce a generic version of that drug.
Perhaps he is neither, just an orphan who carries with him the picture of his handsome parents, killed in a car-crash near the pyramids when he was a boy, together with an abundance of good will which he showers on others.
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Pfizer ( PFE - news - people ) were to gain approval of such an orphan drug, for example, the company might be granted more time to market its blockbuster cholesterol-lowering drug Lipitor before any manufacturer was permitted to produce a generic version of that drug.
What Pollack neglected to mention in the 2006 article was that the same activists who had opposed and obstructed "agbiotech" relentlessly for 20 years were suddenly whining about the "hype" and "over-selling" of its benefits--rather like the teenager convicted of murdering his parents who pleads for mercy from the judge because he's an orphan.
According to the Kansas State Collegian, the university revised the main page of the EcoKat website to remove photos of her and Willie the Wildcat standing together and edit out references to their eco-enforcing tag-team, although as of this writing the full EcoEnforcers page remains online as an orphan web page.
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Tahari, an Israeli orphan with a rough-and-tumble youth, had found success early, but he got stuck in the quicksand of New York nightlife.
Experience shows that Congress will keep troubled programs going indefinitely if they are attached to lots of votes in key states, but if a program takes too long to find a constituency, then it becomes an endangered orphan on Capitol Hill.
Should the settlement be cleared, it will permit Google non-exclusive rights to orphan works (those without an established writer) and will give it a 30 per cent cut of books sold via Google Books, both things that authors have agreed to.
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One idea is to create an incentive for drugmakers comparable to that in the Orphan Drug Act.
According to Rein Strijker, the company's director of orphan-drug development, the promise of an exclusive market in America justified the costly and complex business of making the product (which is harvested from the milk of genetically engineered rabbits).
His philanthropic impulse and an absence of progeny prompted Hershey in 1909 to start a boarding school for orphan boys and to make the school's trust the main holder of Hershey stock.
An estimated 25 million people in the US alone collectively live with some sort of orphan disease.
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