The goal: a drug against osteoporosis, the brittle-bone disease that afflicts 25 million older Americans, mostly women.
Cerezyme, Genzyme's first drug, treats a disease that afflicts fewer than 10, 000 patients globally.
The problem afflicts managers at hundreds of companies, such as Land O'Lakes and American General Corp.
Myeloma afflicts 50, 000 people a year and kills 70% of patients within five years of diagnosis.
It typically afflicts people above age 50, with no prior warning or even risk factors.
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The biggest prize lies in a treatment for Alzheimer's disease, which afflicts 4 million Americans.
The only cure for CML, which afflicts 25, 000 adults in the U.S., is a bone marrow transplant.
This autoimmune disease, in which the patient's own immune system attacks the joints, afflicts 2 million people.
Depriving men of testosterone can cause osteoporosis, the same bone-thinning condition that afflicts some women after menopause.
He entered the field to search for treatments for diabetes, a disease that afflicts his 10-year-old son.
More importantly, however, there is, I believe, a serious disorder that afflicts American political culture at the top.
In July, culminating a three-year search, DeCode pinpointed a gene for schizophrenia, an illness that afflicts Stefansson's brother.
Diabetes afflicts some 21 million Americans, putting them at increased risk of heart attacks, kidney disease and blindness.
Another rampant problem is ventilator-associated pneumonia, which afflicts anywhere from 10% to 25% of patients on the machines.
But there appears to be little relief in sight from the drought that still afflicts 85% of Texas.
Loyalty, or rather the lack of it, is a problem that afflicts Mr Duncan Smith in several ways.
Besides, the curse of rising health-care costs afflicts private as well as public care, Mr Galbraith points out.
It afflicts 19, 000 people in the U.S. each year, killing the vast majority.
As Lord Layard himself says, unemployment visits terrible unhappiness on those it afflicts.
But the same deafness afflicts the same people when they are exhorted to abjure other sorts of unhealthy behaviour.
But in a country where unemployment afflicts about a third of the workforce, it is always tempting to delay.
Although this problem afflicts many areas of development, it threatens to cripple conventional energy projects, which feature scale and complexity.
The worst form, caused by having two bad copies of a particular cholesterol gene, afflicts only a few hundred people.
Who can object to the goal of dramatically reducing hunger and privation that afflicts hundreds of millions around the world?
Already, adult-onset, or type 2, diabetes afflicts about 17 million Americans, although 6 million don't even know they have the disease.
This problem afflicts the rich and famous, as well as those of more modest means, far more often than it should.
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It is a rare type of cancer called pancreatic neuroendocrine tumor that afflicts the hormone producing islet cells in the pancreas.
HGS' best shot at a breakthrough is a new drug that targets lupus, the auto-immune disease that afflicts half a million Americans.
For the 4 million patients who suffer from Alzheimer's disease--the disorder afflicts half of those over 85--the results can't come soon enough.
Americans and Europeans rarely suffer from schistosomiasis, which afflicts 200m people worldwide, or lymphatic filariasis, which makes life miserable for another 120m.
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