目的分析细胞周期素依赖激酶4 (CDK4)在颌骨软骨肉瘤的表达及意义。
AIM To analyze the expression and significance of cyclin dependent kinase 4 (CDK4) in chondrosarcoma of the jaws.
结论：细胞周期素d1的扩增和P 16的缺失与肺癌细胞的高增殖活性密切相关。
CONCLUSION: the high amplification of Cyclin D1 and the high deletion of P16 gene is closely related to the high activity of proliferation of lung cancer.
结果发现，主动脉平滑肌细胞可表达细胞周期素d，其免疫反应产物主要位于细胞核内。
Results Rabbit smooth muscle cells could express cyclin d, the reactant of immune reaction was mainly located in nuclei.
方法：采用多重聚合酶链反应方法，以提取的基因组d NA为模板，在同一反应管中同时扩增细胞周期素d 1基因和P 16基因。
METHODS: Method of multiplex polymerase chain reaction (PCR) was adopted. Cyclin D1 gene and P16 gene were amplified in the same tube, using extracted genome DNA as template.
周期素d 1编码一种全酶的调节亚单位，该酶利用蛋白磷酸化灭活视网膜母细胞瘤蛋白，通过细胞周期G 1 - S期促进肿瘤进展恶化。
Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle.
周期素d 1编码一种全酶的调节亚单位，该酶利用蛋白磷酸化灭活视网膜母细胞瘤蛋白，通过细胞周期G 1 - S期促进肿瘤进展恶化。
Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle.
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