...Hepatocyte-like cells; Differentiation; Hepatocyte growth factor; Fibroblast growth factor-4 [gap=1169]关键词: 骨髓间充质细胞; 肝细胞样细胞; 诱导分化; 肝细胞生长因子; 成纤维细胞生长因子-4 ..
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Differentiation of hES cells into hepatocytes by co-culture with transgenic stromal cells. In part 1, we demonstrated that hES cells could differentiate into hepatocyte-like cells.
二、分阶段富集联合转基因基质细胞共培养诱导人ES细胞向肝脏细胞分化在前述试验研究中,我们证实了人ES细胞能够在特定环境中向肝细胞样细胞分化,但事实上分化的结果仍存在一定争议。
参考来源 - 人胚胎干细胞定向诱导分化为肝细胞的实验研究·2,447,543篇论文数据，部分数据来源于NoteExpress
结论来源于胎儿骨髓的亚全能干细胞可以在体外及肝脏微环境下转化为肝细胞样细胞。
Conclusion The human fetal bone marrow postembryonic pluripotent stem cells can differentiate to hepatocyte - like cells in vitro or in hepatic microcirculation.
肝细胞生长因子(HGF)及胰岛素样生长因子- 1 (IGF - 1)被认为与滋养细胞的增殖或侵蚀有关。
Hepatocyte growth factor (HGF) and insulin-like growth factor-1 (IGF-1) are thought to be concerned with trophoblastic proliferation and invasion.
结论：与动物致癌模型肝中存在卵圆细胞一样，人肝细胞肝癌肝中也存在同样形态和免疫表型特点的卵圆细胞。
Conclusion Oval cells that exhibit the same morphologic and immunophenotypic features as those seen during animal hepatocarcinogenesis are found in human HCC.
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