...分化和维持分化胚胎干细胞的功能,我们推测,人类胚胎干细胞进行更好的三维nanofibrillar表面上诱导分化成肝细胞样的细胞(HLCS)。我们已经证明,在逐步分化诱导,肝谱系的标记表示并最终导致功能的成熟细胞的生成。
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肝细胞生长因子(HGF)及胰岛素样生长因子- 1 (IGF - 1)被认为与滋养细胞的增殖或侵蚀有关。
Hepatocyte growth factor (HGF) and insulin-like growth factor-1 (IGF-1) are thought to be concerned with trophoblastic proliferation and invasion.
结论来源于胎儿骨髓的亚全能干细胞可以在体外及肝脏微环境下转化为肝细胞样细胞。
Conclusion The human fetal bone marrow postembryonic pluripotent stem cells can differentiate to hepatocyte - like cells in vitro or in hepatic microcirculation.
结论:与动物致癌模型肝中存在卵圆细胞一样,人肝细胞肝癌肝中也存在同样形态和免疫表型特点的卵圆细胞。
Conclusion Oval cells that exhibit the same morphologic and immunophenotypic features as those seen during animal hepatocarcinogenesis are found in human HCC.
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