轻微的触摸皮肤感到疼痛难忍等, 多见于丘脑或周围神经病变,精神科见于神经衰弱、癔症、疑病症、更年期综合征等。
...是(1)外部非伤害性刺激因素可引发疼痛,称为异常痛(Allodynia);(2)对伤害性刺激的痛觉反应明显加剧,称为痛觉过敏(Hyperalgesia):
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... hypermotility 运动过度 hyperpathia 痛觉过敏 hyperphosphatemia 高磷酸盐血(症) ...
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痛觉过敏的 hyperalgesic ; hyperalgetic
痛觉过敏区 zone of hyperalgesia
热性痛觉过敏 thermohyperalgesia ; thermal hyperalgesia
肌痛觉过敏 muscularhyperalgesia ; muscular hyperalgesia
继发性痛觉过敏 secondary hyperalgesia
原发性痛觉过敏 primary hyperalgesia ; hyperalgie primaire
温度痛觉过敏 thermal hyperalgesia
痛觉过敏/痛觉超敏 hyperalgesia/allodynia
TRPV4-/-knockout mice also show reduced thermal hyperalgesia in inflammatory pain.
TRPV4基因敲除小鼠也表现出对炎症引起的热痛觉过敏降低。
参考来源 - TRPV4信号通路在大鼠背根神经节慢性压迫后痛觉过敏的机制Furthermore, astrocyte activation is sufficient to result in hyperalgesia, which can be effectively alleviated by interruption of glial including astrocytic function.
星形胶质细胞激活本身足以导致痛觉过敏,而干扰胶质细胞包括星形胶质细胞功能的药物亦能有效抑制痛觉过敏。
参考来源 - 强直刺激坐骨神经诱导脊髓痛敏神经元可塑性机制·2,447,543篇论文数据,部分数据来源于NoteExpress
结果:热痛觉过敏在肿瘤细胞植入后的12 - 18天发生进展。
RESULTS: Thermal hyperalgesia developed between Days 12 and 18 after cancer cell inoculation.
各种因素引起的外周神经损伤可诱发痛觉过敏、感觉倒错等病理现象。
The peripheral nerve injury caused by some pathological factors results in pathological chronic pain, such as hyperalgesia, allodynia, and spontaneous pain ect.
因此,许多研究人员在寻求新的止痛药方时,都会把解除痛觉过敏及异位疼痛列入优先考量。
Many researchers, therefore, have amelioration of hyperalgesia and allodynia foremost in their minds as they hunt for new analgesics.
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