电致孔(Electroporation):电致孔是用瞬时的高电压脉冲在皮肤角质层的质脂双层打出暂时的可逆性水性生物孔道,这些通道的形成为药物的导入提供了途径,使药...
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Therefore, applications of the electroporation transdermal drug delivery technology in clinical has great potential and good prospect.
因此将电致孔经皮给药技术应用于临床,具有巨大的潜力与良好的应用前景。
参考来源 - 电致孔条件下苦参经皮给药的研究·2,447,543篇论文数据,部分数据来源于NoteExpress
目的研究和克服胰岛素在电致孔下经皮传输过程中在皮肤中的滞留,提高胰岛素的经皮渗透速率。
OBJECTIVE To investigate the entrapment of insulin in skin via electroporation, diminish the entrapment and enhance the transdermal delivery of insulin.
结果超过50%的胰岛素在电致孔经皮传输的过程中滞留于皮肤中,滞留量随脉冲时间常数的减小和胰岛素浓度的增加而增加;
RESULTS Over 50% insulin was entrapped in skin during transdermal delivery, and more insulin was entrapped with the shorter pulses and higher concentration of insulin in the solution.
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