抗体亲和力指抗体的抗原结合簇同抗原的抗原决定簇的结合强度。
抗体亲和力(antibody affinity)是抗体与抗原之间相互作用的一种结合能力或强度. 亲和力大即免疫结合既快又牢固,不易重新解离.
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... binding affinity antibody 抗体结合亲和力 affinity isolated antibody 抗体形态 affinity of antibody 抗体亲和力 ...
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Conclusion The success of cloning and reforming of the antibody variable region gene laid a solid foundation for the further research in chimeric antibody 3C8 and antibody affinity change that based on the DNA point mutation technology.
结论抗体可变区基因的成功克隆及拼接,可变区CDR区域、二级拓扑结构分析以及三维结构的模拟,为进一步展开抗体3C8的人源化以及基于DNA点突变技术的抗体亲和力改变实验打下了坚实的基础。
参考来源 - 鼠抗人B7·2,447,543篇论文数据，部分数据来源于NoteExpress
结论错配pcr结合噬菌体展示技术是提高单链抗体亲和力的一种有效且简便的手段。
Conclusion Error-prone PCR is an effective and simple method for affinity maturation of antibodies isolated from a phage antibody library.
该方法体外模拟了抗体亲和力成熟的过程，使得到的抗体不但可以完全的人源化，而且可以具有较高的亲和力。
Because this method was to simulate the process of antibody maturation in vivo, the obtained antibodies was not only fully humanized but also with relatively high affinity.
目的建立一种测定噬菌体抗体相对亲和力的方法。
Objective To establish a method for the measurement of relative affinity of phage antibodies.
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