基因拷贝,是指基因组中拷贝数目少,只有1个或几个的基因,大多数是属于生物体内组成型表达持家基因。
大多数只有一个基因拷贝的人——“携带者”——能够存活下来并将基因传给后代。
Most people with only one copy of the gene—"carriers"—survive and pass the gene to offspring.
他们的方法单刀直入,研究人员选择研究只带了一个这种基因拷贝的老鼠。
To keep things straightforward, the researchers chose to work with mice who carried just one copy of the gene.
博纳病毒基因拷贝4个中有两个严重突变,所以我们的细胞产生的蛋白是不可能来自病毒的。
Two of the four copies of the borna virus gene carry crippling mutations. It's impossible for our cells to make proteins from them.
They basically make many, many copies of their DNA and they make all of their viral proteins and they assemble into new viral units.
它们会生成不计其数的病毒基因拷贝,并翻译生成病毒蛋白,组装成新的病毒单位
Because they've made many copies of their genome and they've made all the proteins that are necessary to - for assembly of a new virus, then this cell can make many new viruses.
因为病毒制造了大量病毒基因组的拷贝,和所有,新病毒组装所需的蛋白质,所以这个细胞就有能力制造大量新的病毒
It's really been a powerful tool in molecular biology because I might have a very small copy of a gene that I'm interested in and I can make enough copies that I can start to do something else with it.
这确实是分子生物学的一项利器,因为我可能只有,很少量的感兴趣的基因拷贝,而我可以马上制造出足够数量的复制品,能使我用作其他用途
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