目的：研究不同药物浓度、不同化学结构的氟喹诺酮类药物对突变选择窗(MSW)内筛选的大肠埃希菌耐药突变体的靶位耐药基因的影响。

OBJECTIVE To investigate the effect of drug concentration, drug structure of fluoroquinolones on the resistant gene of Escherichia coli mutants selected in the mutant selection window (MSW).

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此外，尚有10个氨基酸替代散在于分子内其它区域，这种替代是由于基因突变造成的。

Scattering on other regions of the molecule there were 10 single amino acid substitutions, which could be explained as site-mutations of the gene.

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目的用克隆法研究放射性核素内照射诱发的大鼠外周血淋巴细胞HPRT基因突变情况。

Objective to study HPRT gene mutation in rat peripheral blood lymphocytes induced by internal exposure to radionuclides using cloning method.

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