老板、同事、会议不停地打扰，让我们很难取得实质性的进展。
Constant interruptions from bosses, colleagues and meetings make it hard to get anything substantial done.
由于东南亚国家种种特殊的原因，东盟的经济一体化还未能取得实质性的进展。
Due to various reasons peculiar to the nations of Southeast Asia, ASEAN could not yet make substantial headway when it comes to economic integration.
虽然阿披实看起来是真心诚意地提出民族和解计划，可是这确实是个不小的挑战，而且他也没能取得实质性的进展。
Although Abhisit has appeared genuine in his determination to bring about a process of national reconciliation, it is an immense challenge and he has yet to make any meaningful progress.
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