2 人源化抗体(humanized antibody) 又称重构型抗体、 改型抗体(reshaped antibody) 或 CDR 移植抗体(CDR grafting antibody) : 通过置换三个发夹状环的鼠抗体超变区...
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...类抗体不变区的轻、重链上,代替人类抗体的可变区,缩小了目标抗体与机体自身成分的差异;(2)人源化抗体(humanized antibodies):将鼠单克隆抗体抗原结合位点(互补决定区)移植到人类的IgG上;(3)人类抗体(human antibodies):利用噬箘体表达文库或者转基因...
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首个嵌合抗体(ReoPro)、人源化抗体(Zenapax)及全人抗体(Humira)分别于1994年、1997年和2002年获美国FDA批准上市,这些基因工程抗体具有低的免疫原性和更好的安全性。
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The course of humanize mouse monocloal antibodies has four steps: human and mouse chimeric antibody ,the humanized antibody ,the antibody from phage antibody library,the human antibody expressing from transgenic animnals.
鼠源抗体的人源化改造过程历经:人鼠嵌和抗体、人源化抗体、噬菌体抗体库、转基因动物表达人抗体四个阶段。
参考来源 - 人免疫球蛋白Cγ·2,447,543篇论文数据,部分数据来源于NoteExpress
人源化抗体解决了抗体鼠源性的问题,但CD3单抗激活T细胞引起首剂效应的问题仍然存在。
The immunogenicity of 12F6 in humans has been reduced though humanization. But the first-dose reaction associated with T cell activation by anti-CD3 Abs still exists.
曲妥珠单抗是一种人源化抗体,用于靶向和阻断her2的功能,而后者是由特异基因编码的一种蛋白,具有致癌潜能。
Trastuzumab is a humanised antibody, designed to target and block the function of HER2, a protein produced by a specific gene with cancer-causing potential.
为了降低人抗鼠抗体反应,获得满意的免疫原性,将模拟人卵巢癌抗原的抗独特型单链抗体人源化。
In order to reduce the human anti mouse antibody response and obtain optimal antigenicity, anti idiotype single chain which mimicking ovarian cancer antigen has been humanized.
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