人源化抗体解决了抗体鼠源性的问题，但CD3单抗激活T细胞引起首剂效应的问题仍然存在。
The immunogenicity of 12F6 in humans has been reduced though humanization. But the first-dose reaction associated with T cell activation by anti-CD3 Abs still exists.
曲妥珠单抗是一种人源化抗体，用于靶向和阻断her2的功能，而后者是由特异基因编码的一种蛋白，具有致癌潜能。
Trastuzumab is a humanised antibody, designed to target and block the function of HER2, a protein produced by a specific gene with cancer-causing potential.
为了降低人抗鼠抗体反应，获得满意的免疫原性，将模拟人卵巢癌抗原的抗独特型单链抗体人源化。
In order to reduce the human anti mouse antibody response and obtain optimal antigenicity, anti idiotype single chain which mimicking ovarian cancer antigen has been humanized.
目的：克隆和表达人源化小鼠抗人交联纤维蛋白单链抗体。
Objective: To clone and express humanized mouse ScFv against human cross linked fibrin (HScFv).
本发明还涉及人源化pam4抗体和人pam4抗体以及所述抗体在诊断和治疗中的用途。
The invention further relates to humanized and human PAM4 antibodies, and the use of such antibodies in diagnosis and therapy.
本发明提供一种CD86人源化单克隆抗体，其相关基因序列和表达系统。
The invention provides a CD86 humanized monoclonal antibody, an associated gene order and an expression system thereof.
抗体人源化检测显示，只能被羊抗人抗体识别，不能被羊抗鼠抗体识别。
The expressed product can only be recognized by goat-anti-human antibody rather than goat-anti-mouse antibody.
抗体人源化检测显示，只能被羊抗人抗体识别，不能被羊抗鼠抗体识别。
The expressed product can only be recognized by goat-anti-human antibody rather than goat-anti-mouse antibody.
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