What difference will it make if he knows or not?

他知不知道有什么关系吗？

《牛津词典》

But what difference did it make?

但这又有什么区别呢？

youdao

What difference did it make to England?

到底说了什么，对英格兰来说有什么区别呢？

youdao

Some want an independent review. And the trial's researchers, like Dr.Nelson Michael, of the Walter Reed Institute of Research in the United States, say it's unclear what difference the findings will make for areas like Africa where rates of HIV/AIDS are much higher than among the test population and where there are many strains of the virus.

VOA: standard.2009.10.20

What difference would it make had Frost, as he could have, I suppose, reversed the order of lines 13 and 14?

如果把13行与14行颠倒之后，会发生什么呢？

耶鲁公开课 - 现代诗歌课程节选

What do you think is the biggest difference between living here and in Romania?

你觉得住在这里跟在罗马尼亚最大的不同是什么？

关于罗马尼亚 - SpeakingMax英语口语达人

So the question I would have for you is what difference does the facts make?

NPR: Satellite Tracks Human Rights Abuses

What difference does it make that it looks silly getting in a position to do so?

FORBES: Why S&P Downgrade Makes No Sense To Me

Have you grown poppy before and what difference will this canal make to your life now?

BBC: Programme transcript