...代谢动力学的研究；新方法，由早期以生物效应法为主，近10年来逐渐以血药浓度测定方法为主，药物代谢动力学与药效动力学（PK-PD）结合的研究方法也有报道，中药胃肠动力学的研究思路也有进展。
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pk-pd模型 pk-pd model
pk-pd modeling 药动学
clockwise PK-PD model 短时程速效模式
simultaneous pk-pd modeling 药动药效同步模型
counter clockwise PK-PD model 滞缓慢效模式
effect-compartment PK-PD model 药动学与药效学结合模型
PD-PK结合分析 PD-PK analysis
In this article, we review PK/PD investigation of fluoroquinolones, and give a summary of PK/PD parameter of moxifloxacin and some other fluoroquinolones.
本文简要回顾了部分氟喹酮类药物的PK/PD研究，并对莫西沙星等主要氟喹诺酮类药物PK/PD参数进行总结。
Objective To determine the PK/PD parameters which is more dependent on the inhibition of resistant mutants using vitro pharmacodynamic model.
目的通过体外药效学模型探讨预测抑制细菌耐药突变的PK/PD参数折点。
Parametric method which based on the theory of "effect compartment" suggested by Sheiner (1979) et al includes ten PK models and three PD models.
参数法包括十个药动学模型和三种药效学模型，可以同时求算药动学和药效学参数；
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