Nothing I do makes any difference anyway, so why bother?

不管我做什么都没有区别，那为什么还要费心去做呢？

《柯林斯英汉双解大词典》

So far nothing has been done to enable us to reconcile this difference by a profounder understanding.

我们迄今仍未能通过更深入的理解来调和这一差异。

youdao

I thought long and hard about how to reason with him, how to persuade him to change his mind, but nothing I said made any difference.

我想了很长时间怎样说服他，怎样劝他改变他的想法，我想得很辛苦，但是我的说辞并没有产生多大作用。

youdao

Another reason why the previous attempted merger between Arthur Andersen and Price Waterhouse came to nothing was the difference between their management structures.

ECONOMIST: Accounting

And there have been others on the Republican side or the conservative side who said no matter how much money you spend, nothing makes a difference, so let's just blow up the public school systems.

WHITEHOUSE: Presidential Press Conference

Sincere words to that effect cost nothing and can make the difference between disengagement and productivity.

FORBES: The Joy Of Feeling Valued