...致畸作用（Teratogenesis）；⑥致癌作用（Carccion genesis）；⑦后遗效应（After effect）；⑧首剂效应（First dose reaction）；⑨撤药反应（Withdrawal reaction）等。ADR按病因学分类：①与药物剂量有关的药品不良反应；②与药物剂量无关的药品不良反应。
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first-dose reaction 首剂反应
The results show that the degradation efficiency of DBS increases with the accretion of radiation dose of gamma rays and the degradation reaction of DBS seems following first-order kinetic.
结果表明，丁硫醚的去除率随辐射剂量的增加而上升，去除反应符合一级动力学；
The immunogenicity of 12F6 in humans has been reduced though humanization. But the first-dose reaction associated with T cell activation by anti-CD3 Abs still exists.
人源化抗体解决了抗体鼠源性的问题，但CD3单抗激活T细胞引起首剂效应的问题仍然存在。
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