目的探讨阿霉素对大鼠膈肌的损伤机制及川芎嗪对阿霉素致大鼠膈肌损伤的保护作用。
Objective to explore the mechanism of doxorubicin in impairing diaphragm and to investigate the prevention of doxorubicin -induced diaphragm injury in rats.
上腹部手术更易对呼吸造成不良影响，主要影响因素有：膈肌的刺激、切口疼痛、神经反射刺激、肺动脉压增高等。
Abdominal surgery on more of an adverse respiratory effects of the main factors are: to stimulate the diaphragm, the incision pain, reflex nerve stimulation, such as pulmonary hypertension.
主要防治措施有充分排出腹腔内残余的CO2，膈神经区域阻滞，减少膈肌的损伤及非甾体抗炎药物（NSAID）的全面应用等。
Therapeutic methods include: fully discharge of the residual CO2, avoiding the damage to diaphragm, the application of nonsteroidal anti-inflammatory drugs (NSAID) and phrenic nerve block.
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