感染后肌肉肌纤蛋白基因表达下降，而肌肉泛素蛋白基因表达显著增强。
Expression of muscle myosin heavy chain-1 gene decreased and muscle ubiquitin gene expression increased in sepsis.
目的：研究泛素蛋白质酶途径在癌性恶病质小鼠骨骼肌中的表达以及吲哚美辛(IND)对其的调控作用。
Objective: To investigate the expression of ubiquitin-proteasome pathway in skeletal muscle of cachectic mice and the effect of indomethacin (ind) on it.
p 42是泛素蛋白水解酶通路中26s蛋白水解酶复合体19s帽状调节复合物的一个亚基，也是组成19s调节复合物依赖的蛋白水解酶调节子的一个组成成分。
P42 is one subunit of 19s regulatory complex of 26s proteasome in ubiquitin-proteasome pathway, and it is also one subunit of modulator, which is 19s regulatory complex dependent.
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